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Inhibition of GRP78 expression using siRNA abrogated TNF- or TGF--induced proliferation of FLS and up-regulation of cell cycle protein D1, thereby promoting cell death

In the realm of natural compounds, biochanin A (BCA), extracted from Astragalus, protects against bone loss by inhibiting TfR1 and enhancing FPN, thereby reducing intracellular iron levels

Figure 2 A study showed that D1R signaling blocks the function of LPS-activated macrophages and monocytes and production of inflammatory cytokines (108)

SLC7A11 inhibitors represent a promising therapeutic target by facilitating the induction of ferroptosis in breast cancer